17th International Conference on Pharmacoepidemiology Conference Agenda

August 23th - 26th, 2001
Sheraton Center
Toronto, Canada



Wednesday, August 22 Thursday, August 23 Friday, August 24
Saturday, August 25 Sunday, August 26  


Wednesday, August 22, 2001
09:00-10:30 Finance Committee (Simcoe & Dufferin)
11:00-17:00 Board of Directors (Simcoe & Dufferin)
19:00-21:30 Board Dinner (By Invitation Only)
Thursday, August 23, 2001
07:30-09:00 Committee Meetings
Education (Simcoe)
Publications (Dufferin)
Data Privacy (Kent)
09:30-11:00 Committee Meetings
ByLaws (Simcoe)
Public Policy (Dufferin)
Membership (Kent)
11:00-13:00 Long Range Planning Committee (Simcoe & Dufferin)
12:00-18:00 Exhibitor Set-Up (Sheraton Hall)

Registration (Vide)

13:30-17:30 Pre-ICPE Courses
[A] Introduction to Pharmacoepidemiology
(Grand Ballroom East)

Introduction, Richard Farmer, University of Surrey

Cohort Studies and Simplified Clinical Trials, Annette Stemhagen, Covance Periapproval Services, and Gerry Faich, Pharmaceutical Safety Assessments

Case-Control Studies, Bert Leufkens, Utrecht Institute for Pharmaceutical Sciences

Data-Base Studies, Richard Farmer, University of Surrey

Drug Use Studies, Jerry Avorn, Harvard Medical School

[Note: Registration included as part of meeting registration]



Introduction, Jacques LeLorier, Universite de Montreal

Issues of Interpretation from Multiple Sub-groups, Allan Donner, University of Western Ontario

Cox Regression with Time Dependent Co-Variables, Michael Lewis, EPES
Epidemiology GMBH

The Case-Crossover Design, Malcolm Maclure, British Columbia Ministry of Health

The Etiologic Study Updated, Olli Miettinen, McGill University

[Note: separate registration required. A ticket must be presented to enter this session.]

19:30-21:00 Welcome Reception (Grand Ballroom Centre)
An opportunity to catch up with your colleagues and meet new friends.   Cash Bar
Friday, August 24, 2001
07:00-17:00 Registration (Vide)
Speaker Ready Room (VIP)


07:00-07:30 Poster Set-up (Sheraton Hall
07:00-08:00 Continental Breakfast (Sheraton Hall)
Exhibits (Sheraton Hall
07:30-07:50 Guided Poster Tour (Sheraton Hall)
08:00-10:00 Opening Session (Grand Ballroom East)


Thomas Einarson, Co-Chair, Scientific Program Committee
Paul Stang, Co-Chair, Scientific Program Committee

Kari Stefansson, President & Chief Executive Officer, deCode genetics

Bert Leufkens, President, ISPE, Utrecht Institute for Pharmaceutical Sciences


Saad Shakir, Drug Safety Research Unit
10:00-10:30 Refreshment Break/Viewing of Posters & Exhibits (Sheraton Hall)
[A] VACCINES AND INFECTIONS (Grand Ballroom Centre)
15 Minute Oral Abstract Presentations
Moderator: Elizabeth Andrews

Childhood Vaccinations and Type 1 Diabetes [342]
Frank DeStefano, Catherine A Okoro, John P Mullooly, Robert T Chen (United States)

Risk of Seizures Following Acellular Pertussis Vaccine - Results from a Large Linked Safety Database [356]
Katrin S Kohl, Young Hur, Philip Rhodes, Robert Davis, Robert Chen (United States)

Effectiveness of Influenza Vaccination in Elderly under Everyday Circumstances. A Cohort Study in General Practitioner Practices [294]
Bettie CG Voordouw, Paul D van der Linden, Simon Simonian, Johan van der Lei, Miriam CJM Sturkenboom, Bruno HCh Stricker (The Netherlands)

Meningococcal Group C Conjugate Vaccines: Post-Marketing Surveillance of the UK Mass Vaccination Programme [354]
J Bailey, K Cheng, L Henderson, J Slattery, P Arlett (United Kingdom)

Varicella Vaccine Failure in Children with Asthma [288]
Thomas Verstraeten, John P Mullooly, Hector Izurieta, Aisha Jumaan, Jane Seward, Frank DeStefano, Robert T Chen (United States)

Using Community Pharmacies for Disease Surveillance: A National Survey of Antiviral Resistance [212]
K A Geiringer, J C Veltri, R Boon, D McCammon, A Williams (United States)

Risk Factors for Urological Symptoms from HIV-Protease Inhibitor. The ATHENA Cohort [154]
Jeanne P Dieleman, Miriam CJM Sturkenboom, Marielle Jambroes, Inge C Gyssens, Gerrit-Jan Weverling, Jacob H ten Veen, Gerrit Schrey, Peter Reiss, Bruno HCh Stricker (The Netherlands)

How Important Is Appropriate Empirical Antibiotic Treatment for Intra-Abdominal Infections? [94]
Gillian Libby, Karen Hunter, Janice Broomhall, Diamantis Kofteridis, Douglas Steinke, Eric Taylor, Donald Yin, Peter Davey (United Kingdom, United States)


15 Minute Oral Abstract Presentations
Moderator: Junius Gonzales

What Impact Does Antidepressant Treatment Have on Population Mental Health? [312]
Scott B Patten (Canada)

Antipsychotic-Induced Extrapyramidal Syndromes and CYP2D6 Genotype: A Case-Control Study [362]
Igor Schillevoort, Anthonius De Boer, Jan Van der Weide, Linda SW Steijns, Raymund AC Roos, Paul AF Jansen, Hubert GM Leufkens (The Netherlands)

The Pharmacovigilance of Mirtazapine: Results of a Post-Marketing Surveillance Study on 13 554 Patients in England [40]
Pipasha N Biswas, Lynda V Wilton, Saad AW Shakir (United Kingdom)

Risk for Hyponatremia in Users of Antidepressant Drugs [162]
Kris L Movig, Toine C Egberts, Albert W Lenderink, Hubert G Leufkens (The Netherlands)

Incidence of Arrhythmia and Cardiovascular Mortality among Patients Treated with Risperidone, Thioridazine, or Haloperidol in Saskatchewan Canada [117]
Suellen M Curkendall, JingPing Mo, Judith K Jones, Dale Glasser (United States)

Risk of Cardiac Arrest and Ventricular Arrhythmia Appears To Vary Little by Choice of Antipsychotic Agent [245]
Sean Hennesy, Warren B Bilker, Jill C Santanna, David J Margolis, Stephen E Kimmel, Mary F Morrison, Dale Glasser, Robert F Reynolds, Brian L Strom (United States)

12:30-14:30 Poster Session A /Viewing of Exhibits (Sheraton Hall)
12:30-13:30 Committee/Council Meeting
Development (Kenora)
Ad Hoc Global Develop (Wentworth)
Student Council (Elgin)
13:30-14:30 ISPE General Membership Meeting (Grand Ballroom Centre)


[A] PHARMACOVIGILANCE (Grand Ballroom Center)
15 Minute Oral Abstract Presentations
Moderator: Ralph Edwards

The Weber Effect - Is it Real? [322] Kimberly Brodovicz, Robert Sharrar, Linda Hostelley (United States)

A Study of Celebrex and Vioxx Adverse Event Signals Using the AERS Database
Nandan Padukone (United States)

Using Community Pharmacies To Evaluate the Safety of a Prescription Only Medicine (POM) in an OTC Environment: A Unique Study Method in Europe [216]
I A Gibb, K Miller, J C Veltri, B A Page, A Charlesworth, N Kellett (United Kingdom, United States)

Case-Control Surveillance of Adverse Drug Reactions Requiring Hospitalization in Children [123]
Francesca Menniti-Ippolito, Giuseppe Traversa, Roberto Da Cas, Luciano Sagliocca, Maria Aragione (Italy)

Hospital Admissions Caused by Adverse Drug Events: A Longitudinal Population-Based Study [201] Sebastian Schneeweiss, Joerg Hasford, Martin Goettler, Anne-Kathrin Hoffmann, Ann-Katrin Riethling, Jerry Avorn (Germany, United States)

Factors Influencing Diffusion of Signals from a Spontaneous Reporting System [62] Eugene P van Puijenbroek, Kees van Grootheest, Willem L Diemont, Hubert GM Leufkens, Antoine CG Egberts (The Netherlands)


15 Minute Oral Abstract Presentations
Moderator: Judith Jones

Undertreatment of Hypercholesterolemia in a Population-Based Study in The Netherlands [177]
Aukje K Mantel-Teeuwisse, Anouk D Lindemans, WM Monique Verschuren, Olaf H Klungel, Arijan Porsius, Anthonius de Boer (The Netherlands)

Adherence to Statins Treatment and Readmission of Post Myocardial Infarction Patients: A 6-Year Follow up Study [140]
Li Wei, Jixian Wang, Peter Lindsay, Thomas M MacDonald (United Kingdom)

Long-Term Use of Statins: Studying Compliance with a Repeated Measures Approach [340]
Joshua S Benner, Robert J Glynn, Helen Mogun, Jerry Avorn (United States)

Is Asthma Management of Children Associated with the Socio-Economic Status of the Family? [193]
Lucie Blais, Sylvie Lévesque, Marie-France Beauchesne (Canada)

Rapid Growth of Psychotropic Medication in Children: An American Phenomenon? [149]
Eric Schirm, Hilde Tobi, Julie M Zito, Lolkje TW de Jong - van den Berg (The Netherlands, United States)

Compliance with Labeling for Cylert: Use as Second-Line Therapy and Liver Function Monitoring [293]
Bharati Manda, Carol Drinkard, Mary E Willy, David Graham, Deborah Shatin (United States)

National Health Service Drug Expenditure in Italy(1999-2000): A New Approach To Isolate Quantity, Price and Mix Effects Using Defined Daily Doses [207]
Angelo Menna, Antonio Addis, Massimo Brunetti, Nicola Magrini (Italy)


[C] PAPER DISCUSSION (Grand Ballroom East)
Moderator: Richard Farmer

The Effect of Oral and Transdermal Estrogen Replacement Therapy on Colorectal and Breast Cancer Risk in Postmenopausal Women [333]
Ilona Csizmadi,* Jean-Paul Collet, Andrea Benedetti, Jean-Francois Boivin, James A Hanley (Canada) -- *Edlavitch Award Recipient

Use of Paracetamol or Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and the Risk of Ovarian, Breast, or Colon Cancer [15]
Christoph R Meier, Stephen Schmitz, Hershel Jick (Switzerland, United States)

Academic Council (Kenora)
Industry Council (Wentworth)
Government Council (Elgin)
19:00-21:00 RECEPTION
In honor of Edlavitch Award Recipient & Others
Hart House, University of Toronto
Buses will depart from the Sheraton Centre from 18:30 to 19:00. Buses will return to the Sheraton Centre, with the last bus leaving Hart House at 21:00.

Cash Bar

Saturday, August 25, 2001
07:00-17:00 Registration (Vide)
Speaker Ready Room (VIP)
07:00-07:30 Poster Set-up (Sheraton Hall)
07:00-08:00 Continental Breakfast (Sheraton Hall)
07:00-07:50 Guided Poster Tour (Sheraton Hall)
08:00-10:00 PLENARY SESSION:
Risk Communication (Grand Ballroom East)

Jerry Avorn, Harvard Medical School and Brigham & Women's Hospital
Paul Stang, Galt Associates, Inc.

Frank May, University of Queensland
Anne Trontell, US Food & Drug Administration
Panos Tsintis, UK MCA
Pippa B. Wysong, Freelance science & medical writer
10:00-10:30 Refreshment Break/Viewing of Posters & Exhibits (Sheraton Hall)


15 Minute Oral Abstract Presentations
Moderator: Sam Lesko

Indirect Health Benefits of Viagra (Sildenafil Citrate): Detection of Chronic Disease in Two New England Health Plans [175]
Cheryl Enger, J Alexander Cole, Clorinda Cali, Dale B Glasser, Alexander M Walker (United States)

Regional Differences in Potentially Inappropriate Prescribing Following Admission to Long-Term Care [181]
Irfan A Dhalla, Geoffrey M Anderson, Muhammad M Mamdani, Susan E Bronskill, Kathy Sykora, Paula A Rochon (Canada)

Patient Perceptions Can Be Misleading When Assessing the Clinical Response to Salbutamol Metered Dose Inhalers (MDI) [237]
Mitchell A Levine, Kathryn A Gaebel (Canada)

Unlicensed and Off-Label Drug Prescription in General Practice [122]
Geert W 't Jong, Ingo A Eland, John N Van den Anker, Miriam CJM Sturkenboom, Bruno HCh Stricker (The Netherlands, United States)

An Interrupted Time Series Analysis of the Effect of Drug Use Reviews on the Quality of In-Hospital Prescribing [291]
Jean-Pierre Grégoire, Jocelyne Moisan, Alain Milot, René Verreault, Isabelle Chabot, Michel Gaudet (Canada)

A Classical Training Intervention Is Still Effective in Improving Quality of Prescribing When Geographical Barrier Exist [381] Iwan Dwiprahasto, Erna Kristin, Lucky S Slamet


15 Minute Oral Abstract Presentations
Moderator: Susana Perez-Gutthann

Prescribing of Ulcer-Healing Drugs among Elderly NSAID Users [236]
Karen N van Dijk, Kirsten Ter Huurne, Paul B van den Berg, Corinne S de Vries, Jacobus RBJ Brouwers, Lolkje TW de Jong-van den Berg (The Netherlands, United Kingdom)

An Epidemiological Approach to Assess the Economic Burden of NSAID-Induced Gastrointestinal Events in the Netherlands [278]
Ron MC Herings, Olaf H Klongel (The Netherlands)

The Occurrence of Colonic Ischemia in Relation to Irritable Bowel Syndrome [302]
J Alexander Cole, Rhonda L Bohn, Suzanne F Cook, Alexander M Walker (United States)

Comparison of Tolerability between Two Different Formulations of Omeprazole in the Netherlands [267]
Georgio Mosis, Miriam CJM Sturkenboom, Johan van der Lei (The Netherlands)

Hospitalization for Serious Hepatic or Pancreatic Disease among Antiretroviral Users [29]
Mei-Sheng Duh, Clorinda Cali, Vincent T Ho, Kathleen Shea, Stephan Lanes, Alexander M Walker (United States)

Rates of Venous Thromboembolism and Liver Disease in Women Exposed to Cyproterone Acetate with Ethinyloestradiol [173]
Helen E Seaman, Richard DT Farmer (United Kingdom)

A Cohort Study of the Incidence of Acute Liver Failure in Diabetic Patients Treated with Hypoglycemic Agents
[Late Breaker]
K. Arnold Chan, Alison Truman, Jerry Gurwitz, Judith Hurley, Brian Martinson, Richard Platt, James Everhart, Richard Moseley, Nora Terrault, Lynn Ackerson, Joe Selby (United States)


[C] COMPLEX DISEASE (Grand Ballroom West)
15 Minute Oral Abstract Presentations
Moderator: Thomas MacDonald

Comorbidity as Risk Factor for Overanticoagulation [97]
Fernie JA Penning-van Beest, Erik van Meegen, Frits R Rosendaal, Bruno HCh Stricker (The Netherlands)

Respiratory Medications and Risk of Asthma Death [42]
Stephan F Lanes, Luis A Garcia Rodriguez, Consuelo Huerta (United States, Spain)

Acetaminophen Related Deaths in Scotland, 1993 to 1999 [74]
C L Sheen, J F Dillon, D N Bateman, K Simpson, T M MacDonald (United Kingdom)

Acetaminophen (Paracetamol) and the Risk of Renal and Bladder Cancer [30]
James A Kaye, Marian W Myers, Hershel Jick (United States)

A Survey of Aspirin Use, Non-Prescription NSAID Use, and Cigarette Smoking among Users and Non-Users of Prescription NSAIDs: Estimates of the Effect of Unmeasured Confounding by These Factors on Studies of NSAID Use and Risk of Myocardial Infarction [242]
Priscilla Velentgas, Clorinda Cali, Gail Diedrick, Mary Jane Heinen, Alexander M Walker, Nancy A Dreyer, Kenneth M Verburg (United States)

Incidence Rate and Case Fatality of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Germany [270]
Carlos Martinez, Maja Mockenhaupt, Erwin Schoepf, Juergen Schlingmann (United Kingdom, Germany)

12:00-13:30 Lunch/Poster Session B/Viewing of Exhibits (Sheraton Hall)

18th ICPE Scientific Program Committee Luncheon (City Hall)

13:30-15:30 WORKSHOPS

NOTE: Workshop seating is limited to 25 participants, based on a first-come, first-served basis.


[A] Changing Prescribing Patterns - How Can Theories of Change Help? [199] (Huron)
Flora M Haaijer-Ruskamp, Jerry Avorn, Frank May, Petra Denig (The Netherlands, United States, Australia)


[B] Future Models for the Conduct of Pharmacovigilance [259] (Kent)
Patrick C Waller, Stephen JW Evans (United Kingdom)


[C] The Effect of Electronic Patient Records and Coding Systems on Data Needs in Pharmacoepidemiology [171] (Simcoe)
Anna B Almarsdottir, Maria Heimisdottir, Gyda Bjornsdottir (Iceland)
13:30-15:30 SYMPOSIA

[1] Inception Cohorts in Pharmacoepidemiology [160] (Grand Ballroom East)
Wayne A Ray, Malcolm Maclure, Harry A Guess, Ken J Rothman (United States)

[2] Data Privacy & Pharmacoepidemiology - Is This the End of Research as We Know It? [365] (Grand Ballroom Centre)
Donald J Wilison, Allen Mitchell (Canada, United States)

15:30-16:00 Refreshment Break/Viewing of Posters & Exhibits (Sheraton Hall)
16:00-18:00 WORKSHOPS (Repeated)

NOTE: Workshop seating is limited to 25 participants, based on a first-come, first-served basis.


[A] Changing Prescribing Patterns - How Can Theories of Change Help? [199] (TBD)
Flora M Haaijer-Ruskamp, Jerry Avorn, Frank May, Petra Denig (The Netherlands, United States, Australia)


[B] Future Models for the Conduct of Pharmacovigilance [259] (TBD)
Patrick C Waller, Stephen JW Evans (United Kingdom)


[C] The Effect of Electronic Patient Records and Coding Systems on Data Needs in Pharmacoepidemiology [171] (TBD)
Anna B Almarsdottir, Maria Heimisdottir, Gyda Bjornsdottir (Iceland)
16:00-18:00 SYMPOSIA

[1] Update on Medical Device Epidemiology and Surveillance [105] (Grand Ballroom East)
Roselie A Bright, S Lori Brown, Susan N Gardner, Brockton J Hefflin, Ronald G Kaczmarek, M Kay Patterson, Dale R Tavris (United States)

FDA's Initiatives To Improve Adverse Medical Device Event Surveillance [85] Roselie A Bright, Larry G Kessler (United States); The Medical Product Surveillance Network (MedSuN) Program [88] Susan N Gardner, Marilyn Flack (United States); Quality and Access: The Mammography Quality Standards Act [47] Kay Patterson, Roselie Bright, Helen Barr, Ronald Kaczmarek (United States); Adverse Outcomes Associated with Vacuum Assisted Deliveries [95] Danica Marinac-Dabic, Barry S Schifrin, Roselie A Bright (United States); Prevalence of Silicone Gel Breast Implant Rupture [108] S Lori Brown, Michael S Middleton, Wendie A Berg, Mary Scott Soo, Gene Pennello (United States); Fatal and Serious Complications Associated with Cosmetic Suction Lipectomy [110] S Lori Brown, Anita Kedas, Janos T Bacsanyi, Sherry L Purvis-Wynn (United States); The Global Medical Device Nomenclature [153] Brockton J Hefflin, Thomas P Gross (United States); A System of Meaningful Metrics To Evaluate the Processes and Associated Outcomes of the Center for Devices and Radiological Health of the FDA [17] Dale R Tavris (United States).

[2] Systems To Rate the Strength of the Evidence: From the Population Perspective to Individual Causality Assessment [310] (Grand Ballroom Centre)
Suzanne L West, Jesse A Berlin, John A Clark, Valerie J King (United States)

[3] Assessing Discontinuation of Antihypertensive Drug Therapies, Its Causes and Potential Solutions [179] (Grand Ballroom West)
Olaf H Klungel, Eibert R Heerdink, Judith K Jones, John Urquhart, Hubert GM Leufkens (The Netherlands, United States)

"To delight, inform and challenge visitors through engaging and thought-provoking experiences in science and technology."
Step right up, ICPE participants -- the Centre invites you to peruse, ponder and participate! Circus! at the Ontario Science Centre uses science to explore the wonder of the circus, and the world of the circus to explore science. Imagination becomes reality by observing, examining and enacting the art and science of circus performances.Circus! the exhibition is a highly sensory, interactive, educational extravaganza that will appeal to everyone who has wondered what it would be like to run away and join the circus. []

Buses will depart from the Sheraton Centre from 18:30 to 19:00. Tickets for this evening will be included in the registration packet. Tickets must be presented to board a bus. Buses will return to the Sheraton Centre, with the last bus departing the Science Centre at 23:00.

Cash Bar

Sunday, August 26, 2001
07:00-14:00 Registration (Vide)
07:00-14:00 Speaker Ready Room (VIP)
07:00-07:30 Poster Set-up (Sheraton Hall)
07:30-08:30 Continental Breakfast (Sheraton Hall)
07:30-07:50 Guided Poster Tour (Sheraton Hall)
07:30-08:30 BREAKFAST ROUNDTABLE (Simcoe/Dufferin)
UPDATE: Centers for Education and Research in Therapeutics (CERTS)
Moderator: Hugh Tilson, Chair National Steering, CERTs Program

An opportunity to learn about this new program of seven US-based centers of excellence in practice- and population-based research and demonstration/communication of issues.



[A] METHODS (Grand Ballroom East)
15 Minute Oral Abstract Presentations
Moderator: Jacques LeLorier

Chronic Disease Score as a Predictor of Subsequent Hospitalization: A Multi-HMO Study [324]
Kathleen G Putnam, K Arnold Chan, Paul A Fishman, Diana S Buist, Susan E Andrade, Arne Beck, Myde Boles, Michael J Goodman, Jerry H Gurwitz, Richard Platt (United States)

Method Problems in True Actual Use Drug Safety Trials: The Problems of Comparison and Sample Size Estimation [358]
David C Bradford, Brent C Page, Joseph C Veltri, Clark A Richardson, David L McCammon (United States)

A Bootstrap-Based Approximate Bayesian Approach in a Drug Safety Study [68]
Jixian Wang, Peter T Donnan, Thomas M MacDonald (United Kingdom)

A Validated Tool for Adverse Drug Interaction Assessment [284]
Anne M Holbrook, N Renee Labiris, Jennifer A Pereira, Philip S Wells, Mark A Crowther, James D Douketis (Canada)

The Effect of Cohort-Accrual Block Size in Rolling Propensity Score Matching [131]
John D Seeger, Alexander M Walker, Paige L Williams, Frank M Sacks, Gordon M Saperia (United States)

Evaluation of Prescription Dispensing Patterns for Accutane and Antidepressants in a Large Prescription Claims Database: Application of Prescription Sequence Symmetry Analysis (PSSA) [366]
Maureen P Neary, Winslow Klaskala, John McLane, Susan P Ackermann (United States)


[B] BONE AND JOINT (Grand Ballroom Centre)
15 Minute Oral Abstract Presentations
Moderator: Keith Beard

Relationship between Loop Diuretic Use and Bone Mineral Density- United States 1988-1994 [158]
Michael J Cooper, Anne C Looker, Michael E Mussolino, Mark Eberhardt (United States)

No Association between Inhaled Corticosteroids and Bone Density in a Study on Postmenopausal Women [55]
Sölve Elmståhl, Henrik Ekström, Herbert Galvard, Olof Johnell, Maria Gerhardsson de Verdier, Ensio Norjavaara (Sweden)

Inhaled Corticosteroid Use and Bone Mineral Density in a Large Population Study [132]
Arnulf Langhammer, Ensio Norjavaara, Maria Gerhardsson de Verdier, Roar Johnsen, Leif Bjermer (Norway, Sweden)

Associations between Mortality and Drug Use in Rheumatoid Arthritis: Limitations of Administrative Databases [361]
Anick Berard, Rhonda L Bohn, Robert J Glynn, Helen Mogun, Jerry L Avorn (United States)

Do Traditional NSAIDs Prevent Myocardial Infarctions? [168]
Daniel H Solomon, Robert J Glynn, Raisa Levin, Jerry Avorn (United States)

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Risk of First-Time Acute Myocardial Infarction (AMI) [20]
Raymond G Schlienger, Hershel Jick, Christoph R Meier (Switzerland, United States)


15 Minute Oral Abstract Presentations
Moderator: Susan Sacks

Ischaemic Stroke in Young Women: A Nested Case-Control Study Using the GPRD [180]
Alison L Nightingale, Richard DT Farmer (United Kingdom)

The Effect of Allopurinol on Mortality and Hospitalisations in Congestive Heart Failure; A Retrospective Cohort Study [116]
Peter T Donnan, Allan D Struthers, Thomas M MacDonald (United Kingdom)

Impact of Treatment with Protease Inhibitor (PI) on Myocardial Infarction (MI) Occurrence in HIV Infected Men [145]
Murielle Mary-Krause, Laurent Cotte, Anne Simon, Maria Partisani, Dominique Costagliola (France)

Study of the Assocation between Ischemic Heart Disease and the Use of Alpha-Blockers and Finasteride Indicated for the Treatment of Benign Prostatic Hyperplasia [192]
Patrick C Souverein, Ron MC Herings, Arie J Man in 't Veld, Jean JMCH De la Rosette, Richard DT Farmer, Hubert GM Leufkens (The Netherlands, United Kingdom)

Association between Antihypertensive Treatment and Left Ventricular Geometry. The Rotterdam Study [37]
Gysèle S Bleumink, Jaap Deinum, Arend Mosterd, Jacqueline CM Witteman, Bruno HCh Stricker (The Netherlands)

Amiodarone Induced Thyroid-Dysfunction [182]
Marcel L Bouvy, Eibert R Heerdink, Hubert GM Leufkens, Arno W Hoes (The Netherlands)

10:00-10:30 Refreshment Break/Viewing of Posters & Exhibits (Sheraton Hall)


[A] CENTRAL NERVOUS SYSTEM (Grand Ballroom East)
15 Minute Oral Abstract Presentations
Moderator: Jan Willem van der Velden

Drug or Symptom Induced Depression in Men Treated with Alpha1-Blockers for Benign Prostatic Hyperplasia? A Nested Case: Control Study [169]
Richard DT Farmer, Gary M Clifford (United Kingdom)

Mefloquine Increases the Risk of Serious Psychiatric Events during Travelling - A Nationwide Case-Control Study [50]
Melanie M van Riemsdijk, Miriam CJM Sturkenboom, Bruno HCh Stricker (The Netherlands)

Preservation of Cognitive Function with Vascular Protective Medications: A Longitudinal Analysis of a Community-Based Sample of African-Americans [159]
Michael D Murray, Kathleen A Lane, Sujuan Gao, Rebecca M Evans, Frederick W Unverzagt, Kathleen S Hall, Hugh C Hendrie (United States)

Methylphenidate to Treat Attention-Deficit Hyperactivity Disorder: A Meta-Analysis [357]
Ingunn Bjoernsdottir, Thomas R Einarson, Olafur Th AEvarsson, Sveinn G Einarsson (Canada, Iceland)

The Effect of Short-Term NSAID Exposure on the Rate of Cognitive Decline among Nursing Home Patients with Alzheimer's Disease [227]
Walter L Straus, Suzanne M Vogel, Kate L Lapane (United States)

Increased Incidence of Somnolence with the New Dopamine Agonists in Patients with Parkinson's Disease: A Meta-Analysis of Randomized Controlled Trials [49]
Mahyar Etminan, Ali Samii, Bahi Takkouch, Paula Rochon (Canada, United States, Spain)


[C] WOMEN'S HEALTH (Grand Ballroom West)
15 Minute Oral Abstract Presentations
Moderator: Sheila Weiss

Risk of Venous Thromboembolism from Oral Contraceptives Containing Gestodene and Desogestrel Versus Levonorgestrel: A Meta-Analysis and Formal Sensitivity Analysis [218]
Sean Hennessy, Jesse A Berlin, Judith L Kinman, David J Margolis, Sue M Marcus, Brian L Strom (United States)

Incidence of Acute Myocardial Infarction in Postmenopausal Women in the UK [226]
Susan E Bromley, Corinne S de Vries, Timothy J Williams, Richard DT Farmer (United Kingdom)

Medication Use in Pregnancy; 1976-2000 [341]
Allen A Mitchell, Sonia Hernández-Díaz, Carol Louik, Martha M Werler (United States)

Use of Inhaled Budesonide during Pregnancy Is Not Associated with Any Clinically Relevant Effects on Premature Birth Rate or on Intrauterine Growth Rate [59]
Maria Gerhardsson de Verdier, Ensio Norjavaara (Sweden)

Pregnancy Outcome Following Gestational Exposure to Trazodone/Nefazodone:A Prospective Controlled Study [233]
Adrienne Einarson, Sharon Lavigne, Antonio Addis, Doreen Matsui, Yvette Johnson, Gideon Koren (Canada, United States, Italy)

12:00-14:00 Lunch/Poster Session C/Viewing of Exhibits (Sheraton Hall)

ISPE Board of Directors Luncheon (Long Bar)

14:00-14:15 INSTALLATION OF ISPE PRESIDENT (Grand Ballroom West)
Hubert G. M.Leufkens, Past-President
Jacques LeLorier, ISPE President
14:15-15:45 PLENARY SESSION (Grand Ballroom West)

When Data and Interpretation Conflict
Moderator: Hubert A.G. Leufkens

Brian Strom, academia/journal editor
Kenneth Rothman, academia/journal editor
Patrick Waller, government
Jan Willem van der Velden, industry
Jacques LeLorier, academia

Speakers will addresses the issues surrounding database analysis and the potential for conflicting results and interpretation. With easier access to data, the potential for different research results increases as scientists apply different study designs, methods and analyses. Are these differences threats or opportunities to further knowledge?

15:45-16:00 PRESENTATION OF AWARDS (Grand Ballroom West)

Stanley A. Edlavitch Award

Presented by Stan Edlavitch
Recipent Ilona Csizmadi

Best Poster Presentation & Best Oral Presentation

Presentation by Sean Hennessey
16:00-16:30 THE FINAL WORD (Grand Ballroom West)
Thomas MacDonald, ISPE President-Elect & Chair, 18th ICPE Scientific Program Committtee
16:30 ADJOURNMENT of the 17th ICPE