FINAL PROGRAM
Saturday |Sunday |Monday |Tuesday |Wednesday
| 08:30 - 11:00 | Finance Committee Meeting Köpenick II/III |
| 11:00 - 17:30 | ISPE Board of Directors Meeting (All members are invited to attend) |
| 18:00 - 20:30 | Board of Directors Dinner Meeting Atrium (Private) |
| 08:30 - 10:15 |
Committee Meetings: |
| 10:30 - 12:30 | Committee Meetings: Publications (Tiergarten I) Correspondents (Tiergarten II) Public Policy/Ethics (Tiergarten III) |
| 12:45 - 14:30 | Long Range Planning Committee Meeting (Luncheon) (Members Only) Charlottenberg I |
| 14:30 - 18:00 | Seminar: Introduction to Pharmacoepidemiology Session Moderators: Michael A. Lewis; Ulf Bergman Potsdam I |
| 14:30 - 14:45 | Remarks by session chairs History of Pharmacoepidemiology Objectives of this Introductory Course |
| 14:45 - 15:30 | Dr. Thomas MacDonald Pharmacoepidemiology as a Scientific Discipline Relationship to epidemiology Uses of pharmacoepidemiologic Research (Safety vs Outcome) Issues in using databases as sources of data |
| 15:30 - 16:00 | Dr. Ulf Bergman Introduction to drug utilization studies |
| 16:00 - 16:30 | Dr. Morten Andersen Individualized drug utilization statistics |
| 16:30 - 16:45 | Coffee Break Potsdam Foyer |
| 16:45 - 17:15 | Dr. Jerry Avorn Assessing costs of care/effectiveness of interventions using databases |
| 17:15 - 18:00 | Dr. Bernie O’Brien “Pulp Fiction” or As Good As It Gets?” Building economic models with multiple data sources: The Case of Alzheimer’s Disease |
| 18:30 - 21:00 | WELCOME RECEPTION AND REGISTRATION Special address: Dr. Bergmann - Pohl Parliamentary State Secretary from the German Ministry of Health |
| 07:30 - 09:00 | Poster Session I (Postdam II) Continental Breakfast Session 1: Opening Session Session Chair: Keith Beard (Postdam II) |
| 09:00 - 10:15 | Michael A. Lewis, Past President and local host Hans-Ulrich Melchert, Robert Koch Institute Dieter Ernst, Secretary of State, Berlin Dept. of Economics & Municipal Corporations Keynote Address: Prof. Dr. Alfred Hildebrandt, BfArM Director, Bundesinstitut Für Arzneimittel Und Medizinprodukte German Federal Institute of Drugs and Medical Devices “What Do We Expect from Pharmacoepidemiology Now and in the Future?” Jerry Avorn, President, ISPE “What Does Pharmacoepidemiology Expect to do in the Future.” |
| 10:15 - 10:45 | Coffee Break (Postdam Foyer) Session 2: Joint ISPE - Eurodurg Session (Postdam I) Session Chairs: Michael A. Lewis and Ulf Bergman |
| 10:45 - 11:05 | Antibiotic Prescribing for Preschool Children: A Linked Database Analysis [57] Thomas Einarson, E. Wang, J. Kellner, J. Conly (Canada) |
| 11:05 - 11:25 | Factors Associated with Antiepileptic Drug Use by Elderly Nursing Home Residents [261] Judith Garrard, J. Cloyd, N. Hardie, T. Lackner, I. Leppik (USA) |
| 11:25 - 11:45 | Polypharmacy in General Practice - Differences between Practitioners [248] Lars Bjerrum, J. Søgaard, J. Hallas, J. Kragstrup (Denmark) |
| 11:45 - 12:05 | NSAID Use and GI Toxicity Profiles by Country: A European Study [247] Ulf Bergman (Sweden), B. Wettermark (Sweden), M. Andersen (Denmark), L. Bjerrum (Denmark), A. Vaccheri (Italy), N. Montanaro (Italy) |
| 12:05 - 12:25 | Results from an Educational Intervention in Five Countries to Implement Guidelines for Prescribing in Practice [232] P. Denig (The Netherlands), M. Andrew (Norway), R.Wahlström (Sweden), M. Muskova (Slovakia),E. Hummers Pradier (Germany), C. Stalsby Lundborg (Sweden), FM Haaijer-Ruskamp (The Netherlands) |
| 12:30 - 13:30 | Lunch (La-Cafe, Windergarten) |
| 13:30 - 14:00 |
Poster Session I - Dessert and Coffee |
| 14:00 - 14:15 | Proportional Reporting Ratios: The Uses of Epidemiological Methods for Signal Generation [55] S.J.W. Evans, P. Waller, S. Davis (UK) |
| 14:15 - 14:30 | Identifying and Quantifying Signals Automatically [47] Andrew Bate, M. Lindquist, R. Orre, R. Edwards (Sweden) |
| 14:30 - 14:45 | Anti-ulcer Drugs and Severe Cutaneous Adverse Reactions [71] Judith Kelly (USA) |
| 14:45 - 15:00 | Drug Use in Pregnancy - A Population-based Survey on 15.756 Women [121] Charlotte Olesen (Denmark), F. H. Steffensen (Denmark), L. de Jong-van den Berg (The Netherlands), J. Olsen (Denmark), H.T. Sørensen (Denmark) |
| 15:00 - 15:15 | Pregnancy Outcome Following Prescription for Sumatriptan [123] Charlotte Olesen , F. H.. Steffensen , H.T. Sørensen, G. L. Nielsen, J. Olsen (Denmark) |
| 15:15 - 15:30 | The PEGASUS-project: A Prospective Cohort Study for the Investigation of Drug Utilization in Pregnancy [240] Cornelia Irl, J. Hasford (Germany) Session 3b: ORAL CONTRACEPTIVES AND HORMONE REPLACEMENT THERAPY Session Chair: Samy Suissa (Postdam III) |
| 14:00 - 14:15 | Thromboembolic Stroke in Young Women and Oral Contraceptive Use [67] L.A. J. Heinemann, T. DoMinh, M.A. Lewis (Germany) |
| 14:15 - 14:30 | Analysis of a Suspected Interaction Between Itraconazole and Desogestrel Containing Oral Contraceptives in a Spontaneous Reporting System [161] Eugène P. van Puijenbroek, R. Meyboom, M. HAM Vinks, A. CG Egberts (The Netherlands) |
| 14:30 - 14:45 | Is Hormone Replacement Therapy Protective for Venous Ulcers of the Lower Limbs? [5] Anick Bérard, S. Kahn, J. Collet, L. Abenhaim (Canada) |
| 14:45 - 15:00 | Postmenopausal Risk of Ischemic Heart Disease in Former Users of Ocs in the Dom-Cohort [286] Hubert G. Leufkens, P. AH van Noord, M. de Bruijn, W. JMJ Gorgels, D. Grobbee (The Netherlands) |
| 15:00 - 15:15 | A Prescription Claims Data Assessment of Noncompliance with Hormone Replacement Therapy (HRT); Comparison of Two Definitions of Noncompliance [59] Lela M. Lucy, D.L. Faulkner (USA) |
| 15:15 - 15:30 | The Awareness and Behaviour of Dutch Women Before and After the National Folic Acid Campaign [235] Lolkje TW de Jong-van den Berg, H. EK deWalle, K.M. van der Pal-de Bruin, S. E. Buitendijk, M.C. Cornel (The Netherlands) Session 3c:WORKSHOP: PRESCRIBING PRACTICES IN EDUCATION Chair: Flora M. Haaijer-Ruskamp (Charlottenberg II/III) |
| 14:00 - 15:30 | Improving Prescribing Practices - Testing and Understanding the Effect of Educational Interventions [231] Flora M. Haaijer-Ruskamp (The Netherlands), M. Andrew (Norway), P. Denig (The Netherlands), V. Diwan (Sweden), M. Muskova (Slovakia), C. Stalsby Lundborg (Sweden), R. Wahlstrom (Sweden) |
| 15:30 - 15:45 | Coffee Break (Postdam Foyer) Session 4a: PHARMACOECONOMICS/ OUTCOMES Chair: Bernie O'Brien (Postdam III) |
| 15:45 - 16:00 | A Longitudinal, Population Based, Controlled Study of Healthcare Resource Use and Mortality for Patients with Parkinson's Disease [242] P.T. Donnan, C. Stubbings, D.T. Steinke, T.M. MacDonald, D.G. McDevitt, PG Davey (Scotland, UK) |
| 16:00 - 16:15 | A Cost Analysis of Drugs vs. Laser Surgery to Treat Glaucoma [16] Rhonda L. Bohn, K. Kuntz, L. Pasquale, A. Walker, R. Glynn, J. Gurwitz,J. Avorn (USA) |
| 16:15 - 16:30 | The Effect of Open Access Endoscopy on the Prescribing Costs of Ulcer Healing Drugs [260] Alex McMahon (Scotland, UK), B.M. Goudie (Scotland, UK), G. White (Scotland UK), T.M. MacDonald (Scotland, UK), M. Fe (Ireland, UK) |
| 16:30 - 16:45 | A Health Economic Evaluation of Paclitaxel and Carboplatin Versus Vinorelbine and Ciplatin Combination Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer [322] Neeta Sinha (USA), J.D. Hainsworth (USA), T.R. Einarson (Canada), P.T. Lappas (USA) |
| 16:45 - 17:00 | Compliance with Inhaled Corticosteroids and Hospitalization for Asthma [258] Alex McMahon, B.J. Lipworth, P.G. Davey, A.D. Morris, T.M. MacDonald (Scotland, UK) |
| 17:00 - 17:15 |
Discounting the Economic Evaluation of Preventive Interventions and Compliance [LB22] Session 4b: CARDIOVASCULAR/ASTHMA |
| 15:45 - 16:00 | Prevention of Hypotension Following Cardiopul- monary Bypass by Intravenous Calcium Chloride Administration [79, 80] Stephen E. Kimmel, A. Haghighat, J.A. Berlin, M. A. Sekeres, N. Ellison, B. Strom, V. J. DiSesa (USA) |
| 16:00 - 16:15 | First Time Antihypertensive Drug Use and the Risk of Fatal and Non-Fatal Acute Myocardial Infarction [15] Chantal Bourgault, E. Elstein, M. Baltzan, S. Suissa (Canada) |
| 16:15 - 16:30 | Selection of Anti-hypertensive Drug Classes and Pre Existence of Comorbid Conditions [115] Rajiv Mallick, S. Leader, L. Roht (USA) |
| 16:30 - 16:45 | Exposure to Inhaled Corticosteroids and the Risk of Cataract Extraction in Elderly Patients [200] Edeltraut Garbe (Germany), S. Suissa (Canada), J. LeLorier (Canada) |
| 16:45 - 17:00 | Lack of Intraocular Pressure Effect of Budesonide Inhalation Therapy in Mixed Asthma Population [90] Mei-Sheng Duh (USA), A. Walker (USA), B. Lindmark (Sweden), A. Laties (USA) |
| 17:00 - 17:15 |
Oral Contraceptives and Myocardial Infarction: The MICA Study [52] Session 4c: ACADEMIC DETAILING WORKSHOP |
| 15:45 - 17:15 | Academic Detailing Services for Better Drug Use - A Workshop For Discussions of Problems and Solutions [102] Frank W. May (Australia), L. von Ferber (Germany), J. Avorn (USA), S. Chapman (UK) S. Whicker (Australia), L. Hensjø (Sweden), D. Rowett (Australia) H. McGavock (Ireland) Session 5: COUNCIL MEETINGS |
| 17:30 - 18:30 | Academic Council (Tiergarten I/II) |
| 17:30 - 18:30 | Industry Council Meeting (Köpenick I/II) |
| 17:30 - 18:30 | Government/ Regulatory Council |
| 17:30 - 18:30 | Clinical Meeting (Charlottenberg I/II/III) |
| 19:30 - 22:00 | Reception by the Senate of Berlin Berlin City Hall (Rotes Rathaus) |
| 07:30 - 09:00 | Poster Session II (Postdam II) Continental Breakfast Session 6a: PEER REVIEW - DISCUSSED PAPERS Chair: Richard Farmer (Postdam I) |
| 09:00 - 09:40 | Newer Antidepressants: a Comparison of Tolerability [106] Fiona Mackay, R. Martin, G. Pearce, S. Freemantle, R. Mann (UK) |
| 09:40 - 10:15 | The Differential Risk of Oral Contraceptives: the Impact of Full Exposure History [86] Michael A. Lewis (Germany), K. MacRae (UK), D. Kühl-Habich (Germany) Session 6b: DATA PROTECTION WORKSHOP Chairs: Elizabeth Andrews, Christian von Ferber (Postdam III) |
| 09:00 - 9:15 | Introduction : ISPE recommendations – Status of legislation in the USA Elizabeth Andrews, PhD, MPH Glaxo Wellcome, Inc., USA |
| 09:15 - 09:25 | Report from Canada Donald Willison, PhD McMaster University, Canada |
| 09:25 - 09:35 | Report from Germany Annekarin Bertelsmann, PharmD, DipEpid Federal Institute for Drugs and Medical Devices, Germany |
| 09:35 - 09:45 | Report from Australia Frank May, MA Repatriation General Hospital, Australia |
| 09:45 - 10:00 | Discussion |
| 10:00 - 10:15 |
Resolutions: Standards for Independent Review Boards Christian von Ferber Referees will report on the solutions for central problems of protecting privacy in pharmacoepidemiological and drug utilization research e.g. record linkage or secondary use of health data etc. in their countries. |
| 10:15 - 10:45 | Coffee Break (Postdam Foyer) Session 7A: SPECIAL TOPIC Chair: Jerry Avorn (Postdam I) |
| 10:45 - 12:00 |
Anorexiant Debacle |
| 10:45 - 10:55 | Introduction Dr. H. Leufkens, PhD, PharmD University of Utrecht, Utrecht The Netherlands |
| 10:55 - 11.15 | Patient typing and comparative risk/benefit evalu- ation in drug therapy: from epidemiology to molecules and visa versa. Dr. H. Leufkens, PhD, PharmD University of Utrecht, Utrecht The Netherlands |
| 11:15 - 11:35 | Perspectives of molecular epidemiology in pharmacoepidemiology Dr. Jürgen Brockmöller Humboldt University, Berlin, Germany |
| 10:35 - 12:00 | From genes to epidemiology: osteoporosis as a case example Dr. Huib Burger, MD, PhD University of Utrecht, Utrecht The Netherlands |
| 12:00 - 13:00 | Lunch (La Cafe, Roof Garden ) |
| 12:00 - 13:00 | Correspondents Lunch (Bellevue) |
| 13:00 - 13:30 | Poster Session II - Coffee & Dessert (Postdam II) Session 8: PLENARY SESSION Chair: Jerry Avorn, President (Potsdam I) |
| 13:30 - 14:30 | Membership Meeting |
| 14:30 - 15:30 | JOINT SESSION OF THE INTERNATIONAL SOCIETY FOR PHARMACOECONOMICS AND OUTCOMES RESEARCH (ISPOR) AND THE INTERNATIONAL SOCIETY FOR PHARMACO- EPIDEMOLOGY (ISPE) Chair: Hugh Tilson Pharmacoeconomics: Identifying the Issues for Pharmacoepidemiology [277] Hugh Tilson (USA), N. McElwee (USA), J. Kotsanos (USA), P. Davey (Scotland, UK), T. Einarson (Canada) |
| 15:30 - 16:00 | Coffee Break (Potsdam Foyer) |
| 16:00 - 16:15 | STANLEY A. EDLAVITCH AWARD Chair: Stanley A. Edlavitch |
| 16:15 - 17:45 | DISCUSSION: SCIENTIFIC BASIS OF REGULATORY DECISION MAKING Chair: Gottfried Kreutz |
| 19:00 - 22:00 | Berlin Brass Band at the Renaissance Theater |
| 07:30 - 09:00 | Poster Session III (Potsdam II) Session 9a: PSYCHOTROPICS Chair: Susanne Pérez-Guthann (Potsdam I) |
| 09:00 - 09:15 | Changes in the Treatment of Women with Depression in the United States: The National Ambulatory Medical Care Survey, 1993-1996 [167] Sheila R. Weiss, J. Magno Zito, S. Qi (USA) |
| 09:15 - 09:30 | Changing Patterns of Methylpenidate Use and Costs: 1991-1996 [18] Myde Boles, F. Lynch, R. Johnson, J. Zito, L Phelps (USA) |
| 09:30 - 09:45 | Drug-Induced Parkinsonism in Psychiatric Patients: A Case Control Study [220] I.E.R.M. Schillevoort (The Netherlands), L. Kutikova (The Netherlands), R.M.C. Herings (The Netherlands), G.W.K. Hugenholtz (Czech Republic), R.A.C. Roos (Czech Republic), H.G.M. Leufkens (The Netherlands) |
| 09:45 - 10:00 | Road Traffic Accidents are Associated with Benzodiazepine Use [257] F. Barbone, AD McMahon, PG Davey, AD Morris, DG McDevitt, TM MacDonald (Scotland, UK) |
| 10:00 - 10:15 | Long-Term Use of Benzodiazephines Among Community Dwelling Seniors in Ontario - Area Variation and Patient-Level Predictors [163] Don Willison, A.J, Kirshen, G. Anderson (Canada) Session 9b: ANTI-INFECTIVES Chair: J.W. Van der Velden (Postdam III) |
| 09:00 - 09:15 | Evaluation of the Varicella Vaccine (Varivax) Safety in 89,753 Vaccine Recipients and Long- Term Effectiveness Using of a Retrospective Healthcare Database [26] Paul Coplan, S. Black, H. Shinefield, P. Ray, N. Lewis, J. Hansen, H. Guess (USA) |
| 09:15 - 09:30 | The Safety of Multiple Simultaneous Vaccinations, A Pilot Study [49] Robert T. Chen, D. Gu, H. Takahasi, P. Gargiullo (USA) |
| 09:30 - 09:45 | A Cohort Study on the Risk of Acute Liver Injury Among Users of Ketoconazole and Other Antifungal Drugs [212] Luis A. García Rodríquez (Spain), A. Duque (Spain), J. Castellsague (Spain) S. Pérez Gutthann (Spain), BHCh Stricker (The Netherlands) |
| 09:45 - 10:00 | Case-Crossover Study of Antibiotics and Vaginal Candidiasis: Estimation of Induction Time and Duration of Effect Period [299] Morten Andersen, D. Gaist, J. Hallas, M. Maclure (Denmark) |
| 10:00 - 10:15 | Risk of Tendon-Ruptures Associated with Fluoroqinolone Use [223] PD van der Linden, RMC Herings, HW Nab, BHCh Stricker (The Netherlands) Session 9c: WORKSHOP - CASE CROSSOVER Chair: Morten Anderson, F. Barbone, T. MacDonald, M. Maclure, S. Suissa. |
| 09:00 - 10:30 | What Influences Whether a Case-Crossover Study is Simple or Complex? [118] Morten Andersen (Denmark), F. Barbone (Italy), T. MacDonald (Scotland, UK), M. Maclure (Canada), S. Suissa (Canada) |
| 10:15 - 10:45 | Coffee Break Session 10a: METHODS Chair: Carlos Martinez |
| 10:45 - 11:00 | The Relative Excess Risk: an Alternative Measure of Comparative Risk [76] Samy Suissa (Canada) |
| 11:00 - 11:15 | Utility of Control-to-Case Ratios Greater Than 4: The Role of Phi [70] Sean Hennessy, W. Bilker, J. Berlin, B. Strom (USA) |
| 11:15 - 11:30 | Approaches to Duration Response Analysis [69] Sean Hennessy, P. Allison, W. Bilker, J. Berlin, B. Strom (USA) |
| 11:30 - 11:45 | Accounting for Disease Severity in Assessing the Association of Influenza Vaccine with Asthma Exacerbations [82] Piotr Kramarz, F. DeStefano, P. Gargiullo, R.Chen (USA) |
| 11:45 - 12:00 | Methods for the Estimation of Global Excess Risks of Medications with Multiple Adverse Effects [77] Stephan Rietbrock, (Germany), C. Martinez (Germany), S. Suissa (Canada) |
| 12:00 - 12:15 | Use of Claims Data and a Cancer Registry to Investigate a Hypothetical Adverse Drug Effect [162] Philip Wang, A. Walker, M. Tsuang, E.J. Orav, R. Levin, J. Avorn (USA) Session 10b: ANALGESICS Chair: Kuni Hiashi |
| 10:45 - 11:00 | Proactive Surveillance Program to Assess Ultram (Tramadol) Abuse [324] Theodore Cicero, E. Senay, A. Muñoz (USA) |
| 11:00 - 11:15 | Risk of Seizures Associated with Tramadol: A Cohort Study in an Ambulatory Setting [252] Jacqueline Gardner, D. Blough, D. Shatin, C. Drinkard, L. Powler, R. Alderfer, D. Graham, G. Anderson, A. Stergachis (USA) |
| 11:15 - 11:30 | Non-Steroidal Anti-Inflammatory Drugs and the Incidence of Alzheimer's Disease The Rotterdam Study [88] B.A. In 't Veld, L.J. Launer, A.W. Hoes, A. Ott, A. Hofman, M.M.B. Breteler, B.H.Ch.Stricker (The Netherlands) |
| 11:30 - 11:45 | Alcohol Abuse as Effect Modifier in Risk of GI Complications after NSAID Use [282] C. Ineke Neutel (Canada) |
| 11:45 - 12:00 | Tylenol and Upper Gastrointestinal Bleeding [83] Judith Kelly (USA), D. Kaufman (USA), R. Köff (USA), B.E. Wilholm (Sweden), A. Laszlo (Hungary), S. Shapiro (USA) Session 10c: WORKSHOP - Pharmaco- epidemiological Studies in Germany: An Overview Chair: Annakarin Bertelsman, Hans-Ulrich Melchert |
| 10:45 - 10:50 | Introduction |
| 10:50 - 11:00 | M. Mockenhaupt: The Registry of severe cutaneous adverse reactions (SCAR) |
| 11:00 - 11:05 | C. Martinez: Anti-diabetic drugs and the risk of Stevens-Johnson syndrome and toxic epidermal necrolysis |
| 11:05 - 11:10 | J. Schlingmann: Severe cutaneous adverse reactions (SCAR) due to Chlormezanone and Diciofenac |
| 11:10 - 11:15 | M. Mockenhaupt: Antimycotic agents as etiologic factors for severe cutaneous adverse reactions (SCAR) |
| 11:15 - 11:25 | L. von Ferber: A Nation Wide Random Sample of Health Insurance Members in Germany - Opportunities for Pharmacoepidemiologic Research |
| 11:25 - 11:35 | Gasse: Trends in Antihypertensive drug use in a German population from 1984 to 1995 |
| 11:35 - 11:45 | T. Stürmer/Erb: The Ulm Osteoarthritis Study |
| 11:45 - 11:55 | U. Melchert: The German Health Survey |
| 11:55 - 12:05 | M. Lewis: Adverse event monitoring in a population of German children |
| 12:05 - 12:15 | Discussion |
| 12:15 - 13:15 | Lunch |
| 12:15 - 13:45 | Lunch Meeting - Scientific Program Committee |
| 13:15 - 13:45 | Poster Session III - Dessert and Coffee Session 11: HOT TOPICS |
| 13:45 - 15:00 | Lessons Learned from the Controversies over Calcium Channel Blockers Introduction Dr. A. Walker, Professor of Epidemiology Harvard University, Boston, MA, USA Cancer Data and the Barriers to Dissemination Samuel Lesko, Assoc. Professor Epidemiology Boston University, Boston, MA, USA Cardiovascular Effects of CCBs: What’s known and What’s been claimed. Michael Weber, Professor of Medicine & Assistant Dean State University of New York , New York, USA Calcium Channel Blockers and Suicide Dr. Ulf Bergman, Division of Clinical Pharmacology & Pyschiatry Karolinska Institute, Huddinge University Hospital Huddinge University, Stockholm, Sweden Clinicians: Responsible for or Reacting to the Controversy Paul Hugenholtz, Professor of Cardiology Medical Faculty of Rotterdam, The Netherlands Session 12: CLOSING |
| 15:00- 16:00 | Closing Remarks (Potsdam I) Michael A. Lewis Jerry Avorn Keith Beard |
